Instance ID10838
Regular ExpressionD(S)Gx{2,3}([ST])
Motif InstanceDSGYSS
Bait Uniprot AccessionQ9UKT4
Bait Uniprot IdentifierFBX5_HUMAN
Bait Gene NameFBXO5
Bait OrganismHomo sapiens (Human)
Sequence Position144-149
Critical ResiduesP2; P6
Motif PTM(s)Phosphorylation at Ser-P2 & Ser-P6
Secondary StructureUnknown
Experimental Method(s)Protein kinase assay; Knock out; Classical fluorescence spectroscopy
Interaction ID20838
Interacting DomainWD40 repeat domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)12791266
CommentsThe DSGxxS phospho-dependent degron in human F-box only protein 5 (FBXO5) that binds the F-box/WD repeat-containing protein beta-TrCP (BTRC), a component of the SCF ubiquitin ligase complex

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For queries, suggestions and submission of novel motifs please contact Dr. Sudipto Saha (ssaha4@jcbose.ac.in)