Instance ID10839
Regular ExpressionD(S)Gx{2,3}([ST])
Motif InstanceDSGYNT
Bait Uniprot AccessionQ6PGQ7
Bait Uniprot IdentifierBORA_HUMAN
Bait Gene NameBORA
Bait OrganismHomo sapiens (Human)
Sequence Position496-501
Critical ResiduesP2; P6
Motif PTM(s)Phosphorylation at Ser-P2 & Thr-P6
Secondary StructureUnknown
Experimental Method(s)Mass spectrometry; Protein kinase assay; Co-IP
Interaction ID20839
Interacting DomainWD40 repeat domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)18378770
CommentsThe DSGxxS phospho-dependent degron in Human aurora borealis (BORA) that binds the F-box/WD repeat-containing protein beta-TrCP (BTRC), a component of the SCF ubiquitin ligase complex leading to BORA degradation, which is required for normal mitotic progression

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For queries, suggestions and submission of novel motifs please contact Dr. Sudipto Saha (ssaha4@jcbose.ac.in)