Instance ID10840
Regular ExpressionD(S)Gx{2,3}([ST])
Motif InstanceDSGRGS
Bait Uniprot AccessionP16471
Bait Uniprot IdentifierPRLR_HUMAN
Bait Gene NamePRLR
Bait OrganismHomo sapiens (Human)
Sequence Position348-353
Critical ResiduesP2
Motif PTM(s)Phosphorylation at Ser-P2
Secondary StructureUnknown
Experimental Method(s)Peptide binding to perpetrator; Protein kinase assay; Co-IP
Interaction ID20840
Interacting DomainWD40 repeat domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)15082796
CommentsThe pituitary hormone prolactin (PRL) promotes interaction between Human Prolactin receptor (PRLR) and the F-box/WD repeat-containing protein beta-TrCP (BTRC), substrate recognition subunit of the SCF ubiquitin ligase complex, depending on phosphorylation of serine 349

© 2014 Bose Institute, Kolkata. All rights reserved

For queries, suggestions and submission of novel motifs please contact Dr. Sudipto Saha (ssaha4@jcbose.ac.in)