Instance ID10841
Regular ExpressionD(S)Gx{2,3}([ST])
Motif InstanceDSGNES
Bait Uniprot AccessionP05923
Bait Uniprot IdentifierVPU_HV1BR
Bait Gene Namevpu
Bait OrganismHuman immunodeficiency virus type 1 group M subtype B (isolate BRU/LAI) (HIV-1)
Sequence Position51-56
Critical ResiduesP2
Motif PTM(s)Phosphorylation at Ser-P2 & Ser-P6
Secondary StructureUnknown
Experimental Method(s)NMR; Radiolabel; Confocal microscopy
Interaction ID20841
Interacting DomainWD40 repeat domain
Disease Association(s)Human immunodeficiency virus (HIV) infection
Inhibitor(s)Unknown
Reference(s)14674748, 14561767
CommentsPhosphorylation of the HIV-1 protein Vpu at Ser52 and Ser56 within the DSGXXS motif is required for its interaction with the SCF-betaTrCP ubiquitin ligase complex, which triggers HIV receptor CD4 degradation by the proteasome

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For queries, suggestions and submission of novel motifs please contact Dr. Sudipto Saha (ssaha4@jcbose.ac.in)