Instance ID10842
Regular ExpressionD(S)Gx{2,3}([ST])
Motif InstanceDSGHES
Bait Uniprot AccessionP03230
Bait Uniprot IdentifierLMP1_EBVB9
Bait Gene NameLMP1
Bait OrganismEpstein-Barr virus (strain B95-8) (HHV-4) (Human herpesvirus 4)
Sequence Position210-215
Critical ResiduesP3
Motif PTM(s)Phosphorylation at Ser-P2 & Ser-P6
Secondary StructureUnknown
Experimental Method(s)Co-IP; Mutation analysis
Interaction ID20842
Interacting DomainWD40 repeat domain
Disease Association(s)Epstein-Barr Virus (EBV) infection
Inhibitor(s)Unknown
Reference(s)14523018
CommentsThe Epstein-Barr virus latent membrane protein 1 (LMP1) is a pseudo-substrate of the SCF-betaTrCP ubiquitin ligase complex and the interaction between LMP1 and the F-box protein beta-TrCP (BTRC) restricts the extent of LMP1-induced NF-kappaB signaling

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For queries, suggestions and submission of novel motifs please contact Dr. Sudipto Saha (ssaha4@jcbose.ac.in)