Instance ID10843
Regular ExpressionD(S)Gx{2,3}([ST])
Motif InstanceDSGRGDS
Bait Uniprot AccessionQ53EL6
Bait Uniprot IdentifierPDCD4_HUMAN
Bait Gene NamePDCD4
Bait OrganismHomo sapiens (Human)
Sequence Position70-76
Critical ResiduesP2
Motif PTM(s)Phosphorylation at Ser-P2
Secondary StructureUnknown
Experimental Method(s)Mutation analysis; Protein kinase assay; Mass spectrometry
Interaction ID20843
Interacting DomainWD40 repeat domain
Disease Association(s)Cancer
Inhibitor(s)Unknown
Reference(s)17053147
CommentsThe physical interaction between the tumor suppressor Programmed cell death protein 4 (PDCD4) and the F-box/WD repeat-containing protein beta-TrCP (BTRC) requires the DSGXX(X)S degron and is stimulated by phosphorylation on Ser67 of PDCD4

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For queries, suggestions and submission of novel motifs please contact Dr. Sudipto Saha (ssaha4@jcbose.ac.in)