Instance ID10844
Regular ExpressionD(S)Gx{2,3}([ST])
Motif InstanceDSGIDS
Bait Uniprot AccessionP98174
Bait Uniprot IdentifierFGD1_HUMAN
Bait Gene NameFGD1
Bait OrganismHomo sapiens (Human)
Sequence Position282-287
Critical ResiduesP2
Motif PTM(s)Phosphorylation at Ser-P2 & Ser-P6
Secondary StructureUnknown
Experimental Method(s)Co-IP; Radiolabel; Alanine scanning
Interaction ID20844
Interacting DomainWD40 repeat domain
Disease Association(s)Faciogenital dysplasia
Inhibitor(s)Unknown
Reference(s)15743413
CommentsThe DSGxxS phospho-dependent degron in human FGD1, the Cdc42 guanine nucleotide exchange factor (GEF) responsible for faciogenital dysplasia, that binds the F-box/WD repeat-containing protein beta-TrCP (BTRC), substrate recognition subunit of the SCF ubiquitin ligase complex

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For queries, suggestions and submission of novel motifs please contact Dr. Sudipto Saha (ssaha4@jcbose.ac.in)