Instance ID10846
Regular ExpressionD(S)Gx{2,3}([ST])
Motif InstanceDSGNYS
Bait Uniprot AccessionP17181
Bait Uniprot IdentifierINAR1_HUMAN
Bait Gene NameIFNAR1
Bait OrganismHomo sapiens (Human)
Sequence Position534-539
Critical ResiduesP2; P6
Motif PTM(s)Phosphorylation at Ser-P2 & Thr-P6
Secondary StructureUnknown
Experimental Method(s)Radiolabel; Ubiquitinase assay; Protein kinase assay; Co-IP; Mutation analysis; Pull down
Interaction ID20846
Interacting DomainWD40 repeat domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)15337770, 14532120
CommentsUbiquitination, endocytosis, and lysosomal degradation of the IFNAR1 (interferon alpha receptor 1) subunit of the type I interferon (IFN) receptor is mediated by the SCF ubiquitin ligase complex through a phosphorylation-dependent interaction with F-box and WD repeats protein beta-TrCP2 (FBXW11)

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For queries, suggestions and submission of novel motifs please contact Dr. Sudipto Saha (ssaha4@jcbose.ac.in)