Instance ID10847
Regular Expression(Y)xNx
Motif InstanceYVNI
Bait Uniprot AccessionP35570
Bait Uniprot IdentifierIRS1_RAT
Bait Gene NameIrs1
Bait OrganismRattus norvegicus (Rat)
Sequence Position895-898
Critical ResiduesP1
Motif PTM(s)Phosphorylation at Tyr-P1
Secondary StructureBeta turn
Experimental Method(s)Pull down; Protein kinase assay
Interaction ID20847
Interacting DomainSH2 domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)7504175
CommentsTyrosine-phosphorylated (Y895) rat Insulin receptor substrate 1 (Irs1) binds specifically to the Src homology 2 (SH2) domain of rat Growth factor receptor-bound protein 2

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For queries, suggestions and submission of novel motifs please contact Dr. Sudipto Saha (ssaha4@jcbose.ac.in)