Instance ID10848
Regular Expression(Y)xNx
Motif InstanceYENP
Bait Uniprot AccessionP05067
Bait Uniprot IdentifierA4_HUMAN
Bait Gene NameAPP
Bait OrganismHomo sapiens (Human)
Sequence Position757-760
Critical ResiduesP1
Motif PTM(s)Phosphorylation at Tyr-P1
Secondary StructureBeta turn
Experimental Method(s)SPR; Pull down; Western blot
Interaction ID20848
Interacting DomainSH2 domain
Disease Association(s)Alzheimer's disease
Inhibitor(s)Unknown
Reference(s)19602287
CommentsPhosphorylation of Tyr-757 in the intracellular domain (AID) of Human amyloid beta precursor protein (APP) creates a docking site for the SH2-domain of the human Adapter protein GRB2

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For queries, suggestions and submission of novel motifs please contact Dr. Sudipto Saha (ssaha4@jcbose.ac.in)