Instance ID10849
Regular Expression(Y)xNx
Motif InstanceYVNQ
Bait Uniprot AccessionP04626
Bait Uniprot IdentifierERBB2_HUMAN
Bait Gene NameERBB2
Bait OrganismHomo sapiens (Human)
Sequence Position1139-1142
Critical ResiduesP1
Motif PTM(s)Phosphorylation at Tyr-P1
Secondary StructureBeta turn
Experimental Method(s)NMR
Interaction ID20849
Interacting DomainSH2 domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)12975581, 11500516
CommentsPhosphorylation of Tyr-1139 in the Human Receptor tyrosine-protein kinase erbB-2 (ERBB2) creates a docking site for the SH2-domain of the human adapter protein Growth factor receptor-bound protein 7 (GRB7)

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For queries, suggestions and submission of novel motifs please contact Dr. Sudipto Saha (ssaha4@jcbose.ac.in)