Instance ID10851
Regular Expression(Y)xNx
Motif InstanceYVNV
Bait Uniprot AccessionP29353
Bait Uniprot IdentifierSHC1_HUMAN
Bait Gene NameSHC1
Bait OrganismHomo sapiens (Human)
Sequence Position427-430
Critical ResiduesP1
Motif PTM(s)Phosphorylation at Tyr-P1
Secondary StructureBeta turn
Experimental Method(s)NMR
Interaction ID20851
Interacting DomainSH2 domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)10356320, 9710204
CommentsTyrosine-phosphorylated (Y427) Human SHC-transforming protein 1 (SHC1) binds specifically to the SH2-domain of the human Adapter protein GRB2

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For queries, suggestions and submission of novel motifs please contact Dr. Sudipto Saha (ssaha4@jcbose.ac.in)