Instance ID10855
Regular Expression(Y)xNx
Motif InstanceYSNA
Bait Uniprot AccessionP09619
Bait Uniprot IdentifierPGFRB_HUMAN
Bait Gene NamePDGFRB
Bait OrganismHomo sapiens (Human)
Sequence Position716-719
Critical ResiduesP1
Motif PTM(s)Phosphorylation at Tyr-P1
Secondary StructureUnknown
Experimental Method(s)Mutation analysis; Pull down(GST tag)
Interaction ID20855
Interacting DomainSH2 domain
Disease Association(s)Cancer
Inhibitor(s)Unknown
Reference(s)8940081
CommentsThe SH2 domain of Human Epidermal growth factor receptor GRB-7 can directly bind to the autophosphorylated PDGF beta-receptor (PDGFRB) on Tyr-716

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For queries, suggestions and submission of novel motifs please contact Dr. Sudipto Saha (ssaha4@jcbose.ac.in)