Instance ID10857
Regular Expression(Y)[IV]x[VILP]
Motif InstanceYIDL
Bait Uniprot AccessionP35570
Bait Uniprot IdentifierIRS1_RAT
Bait Gene NameIrs1
Bait OrganismRattus norvegicus (Rat)
Sequence Position1172-1175
Critical ResiduesP1
Motif PTM(s)Phosphorylation at Tyr-P1
Secondary StructureUnknown
Experimental Method(s)Co-IP; Pull down(GST tag)
Interaction ID20857
Interacting DomainSH2 domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)11572799
CommentsTyrosine-phosphorylated (Y1172) rat Insulin receptor substrate 1 (Irs1) binds to the SH2 domain of the rat tyrosine phosphatase Shp2/Ptpn11

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For queries, suggestions and submission of novel motifs please contact Dr. Sudipto Saha (ssaha4@jcbose.ac.in)