Instance ID10858
Regular Expression(Y)[QDEVAIL][DENPYHI][IPVGAHS]
Motif InstanceYQPG
Bait Uniprot AccessionP12931
Bait Uniprot IdentifierSRC_HUMAN
Bait Gene NameSRC
Bait OrganismHomo sapiens (Human)
Sequence Position530-533
Critical ResiduesP1
Motif PTM(s)Phosphorylation at Tyr-P1
Secondary StructureDisordered
Experimental Method(s)X-ray crystallography
Interaction ID20858
Interacting DomainSH2 domain
Disease Association(s)Cancer
Inhibitor(s)Unknown
Reference(s)10360179
CommentsThe human Proto-oncogene tyrosine-protein kinase SRC is maintained in an assembled, inactive conformation by intramolecular interactions of the phosphorylated C-terminal tail (Tyr-527) with the SH2 domain locks the molecule in an inhibited conformation

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For queries, suggestions and submission of novel motifs please contact Dr. Sudipto Saha (ssaha4@jcbose.ac.in)