Instance ID10860
Regular Expression(Y)[QDEVAIL][DENPYHI][IPVGAHS]
Motif InstanceYEPP
Bait Uniprot AccessionQ60787
Bait Uniprot IdentifierLCP2_MOUSE
Bait Gene NameLcp2
Bait OrganismMus musculus (Mouse)
Sequence Position145-148
Critical ResiduesP1
Motif PTM(s)Phosphorylation at Tyr-P1
Secondary StructureExtended conformation
Experimental Method(s)NMR
Interaction ID20860
Interacting DomainSH2 domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)16436281
CommentsThe Src homology 2 (SH2) domain of mouse interleukin-2 tyrosine kinase (Itk) binds to a phosphotyrosine-containing peptide (pY) from mouse Lymphocyte cytosolic protein 2 (Lcp2/Slp-76), a phospholigand binding partner of Itk in T cells

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For queries, suggestions and submission of novel motifs please contact Dr. Sudipto Saha (ssaha4@jcbose.ac.in)