Instance ID10862
Regular Expression(Y)[QDEVAIL][DENPYHI][IPVGAHS]
Motif InstanceYAEI
Bait Uniprot AccessionP34152
Bait Uniprot IdentifierFAK1_MOUSE
Bait Gene NamePtk2
Bait OrganismMus musculus (Mouse)
Sequence Position397-400
Critical ResiduesP1
Motif PTM(s)Phosphorylation at Tyr-P1
Secondary StructureUnknown
Experimental Method(s)Protein kinase assay; Co-IP; Mutation analysis; Western blot
Interaction ID20862
Interacting DomainSH2 domain
Disease Association(s)Cancer
Inhibitor(s)Unknown
Reference(s)7739563
CommentsProto-oncogene c-Src, through its SH2 domain, stably associates with the focal adhesion kinase p125FAK phosphorylated at Tyr-397

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For queries, suggestions and submission of novel motifs please contact Dr. Sudipto Saha (ssaha4@jcbose.ac.in)