Instance ID10863
Regular Expression(Y)[QDEVAIL][DENPYHI][IPVGAHS]
Motif InstanceYEDA
Bait Uniprot AccessionQ60598
Bait Uniprot IdentifierSRC8_MOUSE
Bait Gene NameCttn
Bait OrganismMus musculus (Mouse)
Sequence Position421-424
Critical ResiduesP1
Motif PTM(s)Phosphorylation at Tyr-P1
Secondary StructureUnknown
Experimental Method(s)Colocalization; SPR; Mutation analysis
Interaction ID20863
Interacting DomainSH2 domain
Disease Association(s)Cancer
Inhibitor(s)Unknown
Reference(s)17606906
CommentsThe mouse cytoplasmic adaptor protein Nck1 interacts with Src-phosphorylated cortactin (Cttn) via Tyr 421 to enhance actin assembly

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For queries, suggestions and submission of novel motifs please contact Dr. Sudipto Saha (ssaha4@jcbose.ac.in)