Instance ID10866
Regular Expression(Y)xxQ
Motif InstanceYLPQ
Bait Uniprot AccessionP25049
Bait Uniprot IdentifierTIP_SHV24
Bait Gene NameNot Available
Bait OrganismSaimiriine herpesvirus 2 (strain 484-77) (SaHV-2) (Herpesvirus saimiri)
Sequence Position72-75
Critical ResiduesP1
Motif PTM(s)Phosphorylation at Tyr-P1
Secondary StructureUnknown
Experimental Method(s)Co-IP; Mutation analysis
Interaction ID20866
Interacting DomainSH2 domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)10747948
CommentsThe Tip protein from Herpesvirus saimiri is phosphorylated at Tyr-72 creating a consensus binding site for the DNA binding human transcription factor STAT3 for induction of STAT-dependent transcription during normal T cell activation events

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For queries, suggestions and submission of novel motifs please contact Dr. Sudipto Saha (ssaha4@jcbose.ac.in)