Instance ID10867
Regular Expression(Y)[VLTFIC]xx
Motif InstanceYTHM
Bait Uniprot AccessionP06213
Bait Uniprot IdentifierINSR_HUMAN
Bait Gene NameINSR
Bait OrganismHomo sapiens (Human)
Sequence Position1361-1364
Critical ResiduesP1
Motif PTM(s)Phosphorylation at Tyr-P1
Secondary StructureUnknown
Experimental Method(s)Co-IP; Mutation analysis
Interaction ID20867
Interacting DomainSH2 domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)7983060
CommentsThe phosphorylated YHTM motif in the COOH terminus of the human Insulin receptor (INSR) has the ability to bind to the human PI3-kinase subunit p85-alpha, thereby activating the enzyme and mediating the effect of insulin to activate PI 3-kinase

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For queries, suggestions and submission of novel motifs please contact Dr. Sudipto Saha (ssaha4@jcbose.ac.in)