Instance ID10868
Regular Expression(Y)[VLTFIC]xx
Motif InstanceYVKM
Bait Uniprot AccessionP09793
Bait Uniprot IdentifierCTLA4_MOUSE
Bait Gene NameCtla4
Bait OrganismMus musculus (Mouse)
Sequence Position201-204
Critical ResiduesP1
Motif PTM(s)Phosphorylation at Tyr-P1
Secondary StructureUnknown
Experimental Method(s)Co-IP; Competition binding; Peptide binding to perpetrator
Interaction ID20868
Interacting DomainSH2 domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)8638161
CommentsThe phosphotyrosine (Y201) sequence within the cytoplasmic tail of mouse Cytotoxic T-lymphocyte-associated antigen 4 (Ctla4) mediates binding to the SH2 domain of mouse Protein-tyrosine phosphatase SYP (Ptpn11) suggesting that the RAS pathway and T cell activation through the T cell receptor are regulated by Ctla4-associated SYP

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For queries, suggestions and submission of novel motifs please contact Dr. Sudipto Saha (ssaha4@jcbose.ac.in)