Instance ID10869
Regular Expression(Y)[VLTFIC]xx
Motif InstanceYTPM
Bait Uniprot AccessionQ15303
Bait Uniprot IdentifierERBB4_HUMAN
Bait Gene NameERBB4
Bait OrganismHomo sapiens (Human)
Sequence Position1056-1059
Critical ResiduesP1
Motif PTM(s)Phosphorylation at Tyr-P1
Secondary StructureUnknown
Experimental Method(s)Protein array; Co-IP; Competition binding
Interaction ID20869
Interacting DomainSH2 domain
Disease Association(s)Cancer
Inhibitor(s)Unknown
Reference(s)18721752, 8617750, 10353604
CommentsTyrosine-phosphorylated (Y1056) Human Proto-oncogene-like protein c-ErbB-4 binds to the N- and C-terminal SH2 domains of Human PI3K regulatory subunit alpha (PIK3R1)

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For queries, suggestions and submission of novel motifs please contact Dr. Sudipto Saha (ssaha4@jcbose.ac.in)