Instance ID10871
Regular Expression(Y)[VLTFIC]xx
Motif InstanceYVPM
Bait Uniprot AccessionQ13480
Bait Uniprot IdentifierGAB1_HUMAN
Bait Gene NameGAB1
Bait OrganismHomo sapiens (Human)
Sequence Position447-450
Critical ResiduesP1
Motif PTM(s)Phosphorylation at Tyr-P1
Secondary StructureUnknown
Experimental Method(s)Edman degradation; Pull down(GST tag); Mass spectrometry; Mutation analysis
Interaction ID20871
Interacting DomainSH2 domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)10978177
CommentsTyrosine-phosphorylated (Y447) Human GRB2-associated binder 1 (GAB1) binds to the SH2-domain of the the regulatory subunit (p85-alpha) of human phosphatidylinositol (PI)-3 kinase (PIK3R1)

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For queries, suggestions and submission of novel motifs please contact Dr. Sudipto Saha (ssaha4@jcbose.ac.in)