Instance ID10875
Regular Expression[RKY]xxPxxP
Motif InstanceKPLPPTP
Bait Uniprot AccessionQ06187
Bait Uniprot IdentifierBTK_HUMAN
Bait Gene NameBTK
Bait OrganismHomo sapiens (Human)
Sequence Position186-192
Critical ResiduesP4; P7
Motif PTM(s)Unknown
Secondary StructurePPII helix
Experimental Method(s)Alanine scanning; GPC; NMR
Interaction ID20875
Interacting DomainSH3 domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)11707259
CommentsProline-rich SH3-binding sequence (186-192) in the TH region of Bruton tyrosine kinase (BTK) that stabilize intermolecular self-association with the SH3 domain of another BTK molecule

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For queries, suggestions and submission of novel motifs please contact Dr. Sudipto Saha (ssaha4@jcbose.ac.in)