Instance ID10877
Regular Expression[RKY]xxPxxP
Motif InstanceYDSPCLP
Bait Uniprot AccessionQ06609
Bait Uniprot IdentifierRAD51_HUMAN
Bait Gene NameRAD51
Bait OrganismHomo sapiens (Human)
Sequence Position315-321
Critical ResiduesP7
Motif PTM(s)Unknown
Secondary StructurePPII helix
Experimental Method(s)Pull down; Mutation analysis
Interaction ID20877
Interacting DomainSH3 domain
Disease Association(s)Cancer
Inhibitor(s)Unknown
Reference(s)21653319
CommentsHuman BCR-ABL1 SH3 domain interacts with the proline-rich SH3-binding sequence of human DNA repair protein RAD51, resulting in direct phosphorylation of RAD51 on Y315, which migrates to the nucleus, and enhances formation of the nuclear foci indicative of recombination sites

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For queries, suggestions and submission of novel motifs please contact Dr. Sudipto Saha (ssaha4@jcbose.ac.in)