Instance ID10879
Regular Expression[RKY]xxPxxP
Motif InstanceRTPPKSP
Bait Uniprot AccessionP10636
Bait Uniprot IdentifierTAU_HUMAN
Bait Gene NameMAPT
Bait OrganismHomo sapiens (Human)
Sequence Position547-553
Critical ResiduesUnknown
Motif PTM(s)Unknown
Secondary StructurePPII helix
Experimental Method(s)Mutation analysis
Interaction ID20879
Interacting DomainSH3 domain
Disease Association(s)Alzheimer's disease
Inhibitor(s)Unknown
Reference(s)9763511
CommentsProline-rich SH3-binding sequence in the amino terminus of human Microtubule-associated protein tau (MAPT) that interacts with the SH3 domain of human Tyrosine-protein kinase Fyn and may have a role in neuropathogenesis

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For queries, suggestions and submission of novel motifs please contact Dr. Sudipto Saha (ssaha4@jcbose.ac.in)