Instance ID10880
Regular ExpressionPxxPx[KR]
Motif InstancePPVPPR
Bait Uniprot AccessionQ07889
Bait Uniprot IdentifierSOS1_HUMAN
Bait Gene NameSOS1
Bait OrganismHomo sapiens (Human)
Sequence Position1151-1156
Critical ResiduesUnknown
Motif PTM(s)Unknown
Secondary StructurePPII helix
Experimental Method(s)ITC; Pull down; Co-IP; Competition binding
Interaction ID20880
Interacting DomainSH3 domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)8479541, 23334917
CommentsThe SH3 domains of Adapter protein GRB2 bind to the carboxy-terminal part of hSos1, the human homologue of the Drosophila guanine-nucleotide-releasing factor for Ras, and the GRB2/SOS1 complex couples activated EGF receptor to Ras signalling

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For queries, suggestions and submission of novel motifs please contact Dr. Sudipto Saha (ssaha4@jcbose.ac.in)