Instance ID10883
Regular ExpressionPxxPx[KR]
Motif InstancePPLPER
Bait Uniprot AccessionP29352
Bait Uniprot IdentifierPTN22_MOUSE
Bait Gene NamePtpn22
Bait OrganismMus musculus (Mouse)
Sequence Position614-619
Critical ResiduesP1; P2; P4; P6
Motif PTM(s)Unknown
Secondary StructurePPII helix
Experimental Method(s)NMR; Mutation analysis
Interaction ID20883
Interacting DomainSH3 domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)11685249, 9582365
CommentsMouse C-terminal Src kinase (Csk) takes part in a highly specific, high affinity interaction via its Src homology 3 (SH3) domain with the proline-enriched PEST domain of mouse tyrosine phosphatase PEP in hematopoietic cells

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For queries, suggestions and submission of novel motifs please contact Dr. Sudipto Saha (ssaha4@jcbose.ac.in)