Instance ID10884
Regular ExpressionPxxPx[KR]
Motif InstancePQVPLR
Bait Uniprot AccessionP03406
Bait Uniprot IdentifierNEF_HV1BR
Bait Gene Namenef
Bait OrganismHuman immunodeficiency virus type 1 group M subtype B (isolate BRU/LAI) (HIV-1)
Sequence Position72-77
Critical ResiduesP1; P4
Motif PTM(s)Unknown
Secondary StructurePPII helix
Experimental Method(s)Alanine scanning; Western blot; X-ray crystallography
Interaction ID20884
Interacting DomainSH3 domain
Disease Association(s)Human immunodeficiency virus (HIV) infection
Inhibitor(s)Unknown
Reference(s)7859737, 8681387
CommentsProline-rich (PxxP) motif in HIV-1 Nef that binds to the SH3 domain of human Tyrosine-protein kinase Fyn and are required for the enhanced growth of Nef+ viruses but not for down-regulation of CD4

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For queries, suggestions and submission of novel motifs please contact Dr. Sudipto Saha (ssaha4@jcbose.ac.in)