Instance ID10886
Regular ExpressionPxxPx[KR]
Motif InstancePALPPK
Bait Uniprot AccessionQ13905
Bait Uniprot IdentifierRPGF1_HUMAN
Bait Gene NameRAPGEF1
Bait OrganismHomo sapiens (Human)
Sequence Position284-289
Critical ResiduesP1; P4; P6
Motif PTM(s)Unknown
Secondary StructurePPII helix
Experimental Method(s)X-ray crystallography
Interaction ID20886
Interacting DomainSH3 domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)7735837
CommentsThe SH3 domain of Proto-oncogene c-Crk engages in an unusual lysine-specific interaction to bind the lysine-containing proline-rich peptide from the guanine nucleotide exchange factor C3G with high affinity

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For queries, suggestions and submission of novel motifs please contact Dr. Sudipto Saha (ssaha4@jcbose.ac.in)