Instance ID10890
Regular ExpressionPxxPx[KR]
Motif InstancePPKPSR
Bait Uniprot AccessionP34152
Bait Uniprot IdentifierFAK1_MOUSE
Bait Gene NamePtk2
Bait OrganismMus musculus (Mouse)
Sequence Position750-755
Critical ResiduesP1; P4
Motif PTM(s)Unknown
Secondary StructurePPII helix
Experimental Method(s)Mutation analysis; Pull down; Y2H
Interaction ID20890
Interacting DomainSH3 domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)8662921, 7479864
CommentsThe SH3 domain of Mouse p130cas (CRK-associated substrate) or Bcar1 binds to a proline-rich sequence present in the C terminus of Mouse pp125FAK/ Focal adhesion kinase 1 (Fak1)/ Protein-tyrosine kinase 2 (Ptk2), a kinase which is activated upon cell adhesion, and this interaction is likely to be functionally important in integrin mediated signal transduction

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For queries, suggestions and submission of novel motifs please contact Dr. Sudipto Saha (ssaha4@jcbose.ac.in)