Instance ID10891
Regular ExpressionPxxPx[KR]
Motif InstancePIPPPR
Bait Uniprot AccessionP26662
Bait Uniprot IdentifierPOLG_HCVJA
Bait Gene NameNot Available
Bait OrganismHepatitis C virus genotype 1b (isolate Japanese) (HCV)
Sequence Position2323-2328
Critical ResiduesP3; P4
Motif PTM(s)Unknown
Secondary StructurePPII helix
Experimental Method(s)Mutation analysis; Sequence based prediction; Confocal microscopy; Pull down; Y2H; Co-IP
Interaction ID20891
Interacting DomainSH3 domain
Disease Association(s)Cancer
Inhibitor(s)Unknown
Reference(s)19656877, 16530520
CommentsThe SH3 binding motif of hepatitis C virus (HCV) nonstructural protein 5A (NS5A) interacts with Human BIN1, a tumor suppressor with pro-apoptotic properties, and is important for apoptosis and infectivity as well as may contribute to the pathogenesis of hepatocellular carcinoma

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For queries, suggestions and submission of novel motifs please contact Dr. Sudipto Saha (ssaha4@jcbose.ac.in)