Instance ID10904
Regular Expressionxxx[PV]xxP
Motif InstancePTLPPRP
Bait Uniprot AccessionP25049
Bait Uniprot IdentifierTIP_SHV24
Bait Gene NameNot Available
Bait OrganismSaimiriine herpesvirus 2 (strain 484-77) (SaHV-2) (Herpesvirus saimiri)
Sequence Position135-141
Critical ResiduesP1; P4; P5; P7
Motif PTM(s)Unknown
Secondary StructurePPII helix
Experimental Method(s)Mutation analysis; Co-IP; Pull down
Interaction ID20904
Interacting DomainSH3 domain
Disease Association(s)Cancer
Inhibitor(s)Unknown
Reference(s)11040125
CommentsA proline-rich region in Tip protein of Herpesvirus saimiri strain 484C binds to the SH3 domain and activates the human Proto-oncogene LCK

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For queries, suggestions and submission of novel motifs please contact Dr. Sudipto Saha (ssaha4@jcbose.ac.in)