Instance ID10905
Regular Expressionxxx[PV]xxP
Motif InstanceSPLPSFP
Bait Uniprot AccessionP03495
Bait Uniprot IdentifierNS1_I72A2
Bait Gene NameNS
Bait OrganismInfluenza A virus (strain A/Udorn/307/1972 H3N2)
Sequence Position161-167
Critical ResiduesP4; P7
Motif PTM(s)Unknown
Secondary StructurePPII helix
Experimental Method(s)Co-IP; Western blot; Pull down; Mutation analysis
Interaction ID20905
Interacting DomainSH3 domain
Disease Association(s)Influenza
Inhibitor(s)Unknown
Reference(s)17881440
CommentsSH3 binding motif 1 in influenza A virus NS1 protein mediate binding to the p85 subunit of Human Phosphatidylinositol 3-kinase (PI3K) and is essential for PI3K/Akt signaling pathway activation

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For queries, suggestions and submission of novel motifs please contact Dr. Sudipto Saha (ssaha4@jcbose.ac.in)