Instance ID10910
Regular Expressionxxx[PV]xxP
Motif InstancePPVPPPP
Bait Uniprot AccessionO00499
Bait Uniprot IdentifierBIN1_HUMAN
Bait Gene NameBIN1
Bait OrganismHomo sapiens (Human)
Sequence Position308-314
Critical ResiduesUnknown
Motif PTM(s)Unknown
Secondary StructurePPII helix
Experimental Method(s)Classical fluorescence spectroscopy; Peptide binding to perpetrator; Y2H; NMR; Competition binding; Mutation analysis
Interaction ID20910
Interacting DomainSH3 domain
Disease Association(s)Cancer
Inhibitor(s)Unknown
Reference(s)15992821
CommentsTumor-specific isoforms of human BIN1 are precluded from interaction with c-Myc through an intramolecular polyproline-SH3 domain interaction that inhibits the BIN1 SH3 domain from binding to c-Myc

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For queries, suggestions and submission of novel motifs please contact Dr. Sudipto Saha (ssaha4@jcbose.ac.in)