Instance ID10919
Regular ExpressionxPxAxVxP[^P]
Motif InstanceKPTAYVRPM
Bait Uniprot AccessionQ9UHB7
Bait Uniprot IdentifierAFF4_HUMAN
Bait Gene NameAFF4
Bait OrganismHomo sapiens (Human)
Sequence Position252-260
Critical ResiduesP6
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)Mutation analysis; Co-IP
Interaction ID20919
Interacting DomainTRAF-like domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)15459319
CommentsThe PxAxVxP motif in human AFF4 that mediates binding to and degradation by human E3 ubiquitin-protein ligase SIAH1

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For queries, suggestions and submission of novel motifs please contact Dr. Sudipto Saha (ssaha4@jcbose.ac.in)