Instance ID10972
Regular Expression[ILV](x[ILV]|[ILV]|[ILV]x)[ILV][STDE]{1,10}
Motif InstanceVVISSSEDSD
Bait Uniprot AccessionP29590
Bait Uniprot IdentifierPML_HUMAN
Bait Gene NamePML
Bait OrganismHomo sapiens (Human)
Sequence Position557-566
Critical ResiduesP1; P2; P3
Motif PTM(s)Unknown
Secondary StructureExtended conformation
Experimental Method(s)Western blot; Co-IP; NMR; Mutation analysis
Interaction ID20972
Interacting DomainUnknown
Disease Association(s)Cancer
Inhibitor(s)Unknown
Reference(s)17081985, 21192925
CommentsThe SUMO-interacting motif (SIM) of human Promyelocytic leukemia protein (PML) that mediates interactions with human Small ubiquitin-related modifier 1 (SUMO1)

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For queries, suggestions and submission of novel motifs please contact Dr. Sudipto Saha (ssaha4@jcbose.ac.in)