Instance ID10988
Regular Expression([KR][^ED]{0,5}[ST]xIP[^ED]{5,5})|([^ED]{5,5}[ST]xIP[^ED]{0,5}[KR])
Motif InstanceRPSQIPTPVNN
Bait Uniprot AccessionP25054
Bait Uniprot IdentifierAPC_HUMAN
Bait Gene NameAPC
Bait OrganismHomo sapiens (Human)
Sequence Position2801-2811
Critical ResiduesP5; P6
Motif PTM(s)Unknown
Secondary StructureDisordered
Experimental Method(s)NMR; Pull down; Classical fluorescence spectroscopy; ITC; Mutation analysis
Interaction ID20988
Interacting DomainEBH domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)15616574
CommentsThe C-terminal EBH domain of human End-binding protein 1 (EB1) or MAPRE1 binds to the C-terminal SxIP motif of human Adenomatous polyposis coli (APC) tumor suppressor

© 2014 Bose Institute, Kolkata. All rights reserved

For queries, suggestions and submission of novel motifs please contact Dr. Sudipto Saha (ssaha4@jcbose.ac.in)