Instance ID11006
Regular ExpressionxRxx[PGAV][DEIP]Gx
Motif InstancePRPPVPGE
Bait Uniprot AccessionO15169
Bait Uniprot IdentifierAXIN1_HUMAN
Bait Gene NameAXIN1
Bait OrganismHomo sapiens (Human)
Sequence Position21-28
Critical ResiduesUnknown
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)Co-IP; Pull down; Fluorescence polarization spectroscopy; Alanine scanning
Interaction ID21006
Interacting DomainAnkyrin repeat domain
Disease Association(s)Cancer
Inhibitor(s)Unknown
Reference(s)19759537, 22153077
CommentsThe N-terminal region of ankyrin repeats in human poly(ADP-ribose)polymerase Tankyrase-2 (TNKS2) interacts with the Tankyrase-binding motif in human AXIN1

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For queries, suggestions and submission of novel motifs please contact Dr. Sudipto Saha (ssaha4@jcbose.ac.in)