Instance ID11013
Regular ExpressionEEVD
Motif InstanceEEVD
Bait Uniprot AccessionP07900
Bait Uniprot IdentifierHS90A_HUMAN
Bait Gene NameHSP90AA1
Bait OrganismHomo sapiens (Human)
Sequence Position729-732
Critical ResiduesP1; P2; P3; P4
Motif PTM(s)Unknown
Secondary StructureDisordered
Experimental Method(s)NMR; X-ray crystallography; Alanine scanning; Mutation analysis
Interaction ID21013
Interacting DomainTetratricopeptide repeat (TPR) domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)16531226, 10786835, 11877417, 10567422
CommentsThe C-terminal sequence EEVD in human Heat shock protein HSP 90-alpha (HSP90AA1) that binds to the TPR (tetratricopeptide repeat) domain of human Stress-induced-phosphoprotein 1 (STIP1)/ Hsc70/Hsp90-organizing protein (Hop)

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For queries, suggestions and submission of novel motifs please contact Dr. Sudipto Saha (ssaha4@jcbose.ac.in)