Instance ID11033
Regular Expression[FY]xLxP
Motif InstanceFNLAP
Bait Uniprot AccessionQ9BSI4
Bait Uniprot IdentifierTINF2_HUMAN
Bait Gene NameTINF2
Bait OrganismHomo sapiens (Human)
Sequence Position258-262
Critical ResiduesP1; P3
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)Mutation analysis; ITC; Co-IP; X-ray crystallography
Interaction ID21033
Interacting DomainTRFH domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)18202258
CommentsThe telomeric repeat binding factor (TRF) homology (TRFH) domain of human Telomeric repeat-binding factor 1 (TERF1/PIN2/TRF1) recognizes and directly interacts with the [Y/F]XL motif in human TERF1-interacting nuclear factor 2 (TINF2/TIN2) and regulates telomere maintenance

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For queries, suggestions and submission of novel motifs please contact Dr. Sudipto Saha (ssaha4@jcbose.ac.in)