Instance ID11034
Regular Expression[FY]xLxP
Motif InstanceYLLTP
Bait Uniprot AccessionQ9H816
Bait Uniprot IdentifierDCR1B_HUMAN
Bait Gene NameDCLRE1B
Bait OrganismHomo sapiens (Human)
Sequence Position504-508
Critical ResiduesP1; P3; P5
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)X-ray crystallography; ITC; Co-IP; Mutation analysis
Interaction ID21034
Interacting DomainTRFH domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)18202258
CommentsThe telomeric repeat binding factor (TRF) homology (TRFH) domain of human Telomeric repeat-binding factor 2 (TERF2/TRF2) recognizes and directly interacts with the [Y/F]XL motif in human 5' exonuclease Apollo/ DNA cross-link repair 1B protein (DCLRE1B) and regulates telomere maintenance

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For queries, suggestions and submission of novel motifs please contact Dr. Sudipto Saha (ssaha4@jcbose.ac.in)