Instance ID11036
Regular Expression[KR]{1,4}[KR]x[KR]Wx
Motif InstanceKRKSRWD
Bait Uniprot AccessionO75533
Bait Uniprot IdentifierSF3B1_HUMAN
Bait Gene NameSF3B1
Bait OrganismHomo sapiens (Human)
Sequence Position333-339
Critical ResiduesP6
Motif PTM(s)Unknown
Secondary StructureDisordered
Experimental Method(s)X-ray crystallography; NMR; Pull down; Mutation analysis; ITC
Interaction ID21036
Interacting DomainUHM domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)17589525, 16376933
CommentsHuman Splicing factor 45 (SPF45)/ RNA-binding motif protein 17 (RBM17) binds to the UHM-ligand motif (ULM) present in human Splicing factor 3B subunit 1 (SF3B1) for regulating the alternative splicing of apoptosis regulatory gene FAS

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For queries, suggestions and submission of novel motifs please contact Dr. Sudipto Saha (ssaha4@jcbose.ac.in)