Instance ID11038
Regular Expression[PA][^P][^FYWIL]S[^P]
Motif InstancePSSSH
Bait Uniprot AccessionQ00987
Bait Uniprot IdentifierMDM2_HUMAN
Bait Gene NameMDM2
Bait OrganismHomo sapiens (Human)
Sequence Position147-151
Critical ResiduesP4
Motif PTM(s)Unknown
Secondary StructureDisordered
Experimental Method(s)X-ray crystallography; Mutation analysis; Pull down; Classical fluorescence spectroscopy
Interaction ID21038
Interacting DomainMATH domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)16474402
CommentsThe N-terminal TRAF-like domain of human Deubiquitinating enzyme USP7 binds to a P/AXXS motif (147-151) in human E3 ubiquitin-protein ligase MDM2

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For queries, suggestions and submission of novel motifs please contact Dr. Sudipto Saha (ssaha4@jcbose.ac.in)