Instance ID11057
Regular ExpressionPPxY
Motif InstancePPEY
Bait Uniprot AccessionQ05128
Bait Uniprot IdentifierVP40_EBOZM
Bait Gene NameVP40
Bait OrganismZaire ebolavirus (strain Mayinga-76) (ZEBOV) (Zaire Ebola virus)
Sequence Position10-13
Critical ResiduesP4
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)Ubiquitinase assay; Western blot; Mutation analysis
Interaction ID21057
Interacting DomainWW domain
Disease Association(s)Ebola virus infection
Inhibitor(s)Unknown
Reference(s)11095724
CommentsThe PPxY motif within the Membrane-associated Matrix protein VP40 of Ebola virus interacts physically and functionally with mouse E3 ubiquitin-protein ligase Nedd4

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For queries, suggestions and submission of novel motifs please contact Dr. Sudipto Saha (ssaha4@jcbose.ac.in)