Instance ID11059
Regular ExpressionPPxY
Motif InstancePPAY
Bait Uniprot AccessionQ15303
Bait Uniprot IdentifierERBB4_HUMAN
Bait Gene NameERBB4
Bait OrganismHomo sapiens (Human)
Sequence Position1053-1056
Critical ResiduesP2; P4
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)Co-IP; Confocal microscopy; Pull down; Mutation analysis
Interaction ID21059
Interacting DomainWW domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)18334649
CommentsThe PPXY motif within the CYT-1 isoforms of human Receptor tyrosine-protein kinase ERBB4 provides a binding site for human WW domain-containing E3 ubiquitin-protein ligase ITCH and is necessary both for ubiquitination and endocytosis of CYT-1 isoforms

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For queries, suggestions and submission of novel motifs please contact Dr. Sudipto Saha (ssaha4@jcbose.ac.in)