Instance ID11062
Regular ExpressionPPxY
Motif InstancePPAY
Bait Uniprot AccessionP37088
Bait Uniprot IdentifierSCNNA_HUMAN
Bait Gene NameSCNN1A
Bait OrganismHomo sapiens (Human)
Sequence Position641-644
Critical ResiduesP4
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)Co-IP; RNA interference; Ubiquitinase assay; Mutation analysis; Western blot
Interaction ID21062
Interacting DomainWW domain
Disease Association(s)Liddle's Syndrome
Inhibitor(s)Unknown
Reference(s)17502380
CommentsThe PPXY motif of human Epithelial Na(+) channel subunit alpha (SCNN1A) that binds to the WW domain of human E3 ubiquitin-protein ligase NEDD4L/Nedd4-2

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For queries, suggestions and submission of novel motifs please contact Dr. Sudipto Saha (ssaha4@jcbose.ac.in)