Instance ID11063
Regular ExpressionPPxY
Motif InstancePPPY
Bait Uniprot AccessionO15350
Bait Uniprot IdentifierP73_HUMAN
Bait Gene NameTP73
Bait OrganismHomo sapiens (Human)
Sequence Position484-487
Critical ResiduesP4
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)Ubiquitinase assay; Co-IP; Pull down(GST tag); Mutation analysis
Interaction ID21063
Interacting DomainWW domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)15678106
CommentsThe human WW domain-containing E3 ubiquitin-protein ligase ITCH selectively binds and ubiquitinates the human Tumor protein TP73 via the PPXY motif of TP73, which results in the rapid proteasome-dependent degradation of TP73

© 2014 Bose Institute, Kolkata. All rights reserved

For queries, suggestions and submission of novel motifs please contact Dr. Sudipto Saha (ssaha4@jcbose.ac.in)