Instance ID11066
Regular ExpressionPPxY
Motif InstancePPPY
Bait Uniprot AccessionP28282
Bait Uniprot IdentifierUL56_HHV2H
Bait Gene NameUL56
Bait OrganismHuman herpesvirus 2 (strain HG52) (HHV-2) (Human herpes simplex virus 2)
Sequence Position49-52
Critical ResiduesUnknown
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)Mutation analysis; Classical fluorescence spectroscopy; Co-IP; Western blot; Y2H
Interaction ID21066
Interacting DomainWW domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)18353951
CommentsThe PY motif (49-52) of the UL56 protein of Herpes simplex virus type 2 that binds to the WW domain of human E3 ubiquitin-protein ligase NEDD4 and thereby increased ubiquitinated NEDD4, which was actively degraded in HSV-2 infected cells

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For queries, suggestions and submission of novel motifs please contact Dr. Sudipto Saha (ssaha4@jcbose.ac.in)