Instance ID11067
Regular ExpressionPPxY
Motif InstancePPEY
Bait Uniprot AccessionQ4VCS5
Bait Uniprot IdentifierAMOT_HUMAN
Bait Gene NameAMOT
Bait OrganismHomo sapiens (Human)
Sequence Position239-242
Critical ResiduesP4
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)Pull down; Co-IP; Mutation analysis
Interaction ID21067
Interacting DomainWW domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)21205866
CommentsThe PPXY motif of human Angiomotin (AMOT), a component of the Hippo tumor suppressor pathway, that binds to the WW domain of human transcription coactivator Yes-associated protein (YAP1/YAP65), thereby inhibiting YAP oncoprotein through phosphorylation-induced cytoplasmic retention and degradation

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For queries, suggestions and submission of novel motifs please contact Dr. Sudipto Saha (ssaha4@jcbose.ac.in)